General Information

  • ID:  hor001435
  • Uniprot ID:  P83322
  • Protein name:  SIFamide
  • Gene name:  NA
  • Organism:  Penaeus monodon (Giant tiger prawn)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  brain and thoracic ganglion
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Penaeus (genus), Penaeidae (family), Penaeoidea (superfamily), Dendrobranchiata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0003674 molecular_function
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005575 cellular_component; GO:0005576 extracellular region

Sequence Information

  • Sequence:  RKPPFNGSIF
  • Length:  10
  • Propeptide:  GYRKPPFNGSIF
  • Signal peptide:  NA
  • Modification:  T10 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001435_AF2.pdbhor001435_ESM.pdb

Physical Information

Mass: 132305 Formula: C55H83N15O13
Absent amino acids: ACDEHLMQTVWY Common amino acids: FP
pI: 11.65 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -62 Boman Index: -1869
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 39
Instability Index: 2495 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21459120
  • Title:  Visualization of Neuropeptides in Paraffin-Embedded Tissue Sections of the Central Nervous System in the Decapod Crustacean, Penaeus Monodon, by Imaging Mass Spectrometry